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FAQ for PLO Gel and PLO Kits
What is Transderma PLO Gel?
Transderma PLO Gel is a unique topical base consisting of lipids and a polymer formulated in a vehicle of water and alcohol to yield an elegant gel. The base is compatible with a wide range of drugs which may be either dissolved or suspended. The unique penetrating power of Transderma makes an ideal vehicle to deliver therapeutic agents to sites within the skin or to facilitate their transport through the skin to reach other body tissues and fluids. It has already gained acceptance as the vehicle of choice for the anti-inflammatory drug Diclofenac, and for topical hormone replacement therapy using Progesterone and Estrogen.
What is the difference between Transderma PLO Gel and Transderma PLO Kits?
PLO Gel and PLO Gel is a pharmaceutically elegant premixed finished gel and is more convenient to use.
PLO kits are used in components to make up PLO Gel. Depending on the matrix of the active drugs that are required, the compounder can adjust the amount of emulsification (Hydrophilic/Pluronic Gel) to incorporate higher amounts of active medication.
Do I need to use a solvent when compounding medications, active drugs into PLO Gel and PLO Kits?
Active drugs can be premixed with solvents and incorporated into PLO Gel and PLO kits. For the latter, the solvent would be used in dissolving the active drug into the Organic/Lecithin Isopropyl Palmitate Solution phase. PLO kits are supplied with alcohol for this purpose. Solvents are usually used to allow easier compounding but can affect the viscosity of the finished gel.
How much PLO Gel does a patient apply and how quickly will it work?
For the non-steroidal anti-inflammatories, it is not necessary to apply a measured aliquot as it is being used for local transdermal absorption. A small amount is applied to the affected areas three or four times per day as directed by a physician. Complete relief may take two to three days.
Does PLO Gel have a DIN #?
Transderma PLO Gels do not have Drug Identification Numbers. Some Provinces, Government insurance plans may cover the active drug compounded into the PLO delivery system.
What is the shelf life of the finished compounded PLO Gel/PLO Kit?
Transderma PLO Gels and Kits can be stored at room temperature for up to one year after compounding.
Where can I buy PLO Gel?
PLO Gels, PLO Gel and PLO Kits can be ordered from your local wholesaler, please check wholesale listings information.
Can I crush tablets or capsules to use in the PLO Gel?
In general, it is preferable to use pure chemical powder. Crushing tablets will incorporate the incipient ingredients found in capsules and tablets. Powders are typically less expensive and generally preferable, as the ingredients are ready to mix. Most off-patent medications such as diclofenac sodium, are available in pure powder form from your local wholesaler.