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Products

TD Lipo Base

Introduction

This cosmetically elegant liposomal cream base is an alternative to traditional PLO gel for the transdermal delivery of lipophilic APIs. It is an absolute answer to the challenges in transdermal delivery of lipophilic APIs such as Diclofenac, Progesterone and Testosterone.  This white, robust cream base can accommodate ever-increasing percentages of APIs beyond the range of PLO Ultramax Gel and Trans Pen Cream.

 

Available Sizes:

100G, 500G, 18KG

Where to buy

This liposomal delivery system is designed to improve dermal penetration of a variety of lipophilic APIs being used in pain management and HRT compounding.

TD Lipo Highlighted Benefit

  • Cosmetically appealing
  • Non-greasy cream base
  • Enhanced dermal penetration of lipophilic APIs
  • Easy to incorporate APIs
  • Can incorporate higher percentage of APIs than traditional PLO Gel

 Application

  • Pain management
  • HRT

API Compatibility Chart

API

Common Concentration (s)

API

Common Concentration (s)

Amitriptyline

0.5 to 2%

Ketoprofen

2 to 15%

Baclofen

1 to 5 %

Lidocaine

2 to 10%

Benzocaine

2 to 5 %

Menthol

1 to 5%

Buspirone

2.5 mg/ml

Methimazole

1 to 5%

Camphor

1 to 2%

Metoclopramide

1 to 2%

 

Capsaicin

 

0.75 to 1%

 

 

Metronidazole

1 to 2%

Clomipramine

5 to 7.5%          

Methyl Salicylate

5 to 15%

Cyclobenzaprine

0.5 to 2%

Nifedipine

0.5 to 10%

Dehydroepiandrosterone

1 to 2.5%

 

Piroxicam

5 to 10%

Diclofenac

2.5 to 15%

Pentoxiphyline

3 to 5%

Diltiazem

 

2 to 5%

Progesterone

1 to 5%

Estradiol

0.1 to 1 mg/ml

Promethazine

2.5 to 5%

Estriol

 

0.2 to 2 mg/ml

Sildenafil

 

1%

Gabapentin

 

6%

Tadalafil

0.2%

Ibuprofen

2 to 10%

Testosterone

0.5 to 2.5%

Ketamine

2 to 5%

Tetracaine

3 to 5%

***The above recommended concentrations are for transdermal application. The concentration is required to be adjusted for any other route of administration such as mucosal, vaginal or rectal delivery.

 

Essential Oil Compatibility Chart

Essential Oil

Common Concentration (s)

Essential Oil

Common Concentration (s)

Argan Oil

1 to 8%

Myrrh Essential Oil

1 to 3%

Eucalyptus Essential Oil

1 to 3%

Thyme Essential Oil

0.5 to 2%

Grapefruit Essential Oil

1 to 3%

Tea Tree  Essential Oil

1 to 5%

Lavender  Essential  Oil

1- 2.5%

 

 

Rose Hip  Essential Oil

0.5 to 3%

Jojoba Oil

1 to 10%

 

 

Peppermint  Essential Oil

1 to 3%

Winter Green Essential Oil

1 to 3%

Spearmint  Essential Oil

1 to 3%

 

Examples of compounding formulations with TD Lipo Base

Diclofenac 10% Spearmint Essential Oil 1%

Diclofenac 10% Lidocaine 4% in TD Lipo

Progesterone 5% in TD Lipo

Diclofenac 10% Cyclobenzaprine 2% Ketamine 5% in TD Lipo

Gabapentin 6% Lidocaine  4% in TD Lipo

Testosterone 2.5 % in TD Lipo

Capsacin 0.05% Camphor 5% Menthol 2% Methyl Salicylate 10% in TD Lipo

DHEA 25 mg/ml in TD Lipo

Amitryptiline 2% Baclofen 2% in TD Lipo

 

Compounding tips:

Ethoxy Diglycol, Glycerin, MCT oil, Mineral oil or Propylene Glycol are recommended as levigating agent.

 

TD Lipo Physicochemical Characteristics

pH

 5 – 6

Viscosity

65,000 – 95,000 CPS

Color

White

Dosage Form

Cream

 

 

Disclaimer: Transderma Pharmaceuticals Inc. has provided the formula and instructions above as a model for educational purposes only on the basis of recognized compendia and texts or references. Transderma Pharmaceuticals Inc. takes no responsibility for the validity or accuracy of this information or for its safety or effectiveness, nor for any use thereof, which is at the sole risk of the licensed pharmacist. Adjustments may be needed to meet specific patient needs and in accordance with a licensed prescriber’s prescription. The pharmacist must employ appropriate tests to determine the stability of this suggested formula. Transderma Pharmaceuticals Inc., its owners, officers, agents, contractors, affiliates and employees cannot be held liable to any person or entity concerning claims, loss or damage caused by, or alleged to be caused by, directly or indirectly, the use or misuse of the information contained in this suggested formula. In all cases, it is the responsibility of the licensed pharmacist to know the law, to compound any finished product and to dispense these products in accordance with Health Canada and FDA guidelines and appropriate Provincial Drug Schedules and Provincial or Territorial Pharmacy Practice Standards.

Toll Free: 1.800.663.1002
Website: www.xenexlabs.com

Xenex has been supplying the highest quality products, delivered by qualified professionals to the Canadian compounding profession for over 30 years. Xenex focuses on the compounding pharmacist and has built a valuable set of support services to provide the pharmacist with education, formulation support and competitively priced product, delivered by a knowledgeable sales and customer services team.