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Products

TD PLO Gel

Introduction

TD PLO gel represent a ready-to-use PLO gel (Premium Lecithin Organogel).  This base is designed for the transdermal delivery of lipophilic APIs such as NSAIDs and bioidentical hormones. PLO gels have already gained acceptance as the transdermal vehicle of choice for a variety of drugs including Diclofenac, Ibuprofen, Ketamine, Progesterone and Testosterone.

Available Sizes:

100G, 500G

Where to buy

Transderma PLO gel represents a ready-to-use PLO gel. This base is designed for transdermal delivery of lipophilic APIs such as NSAIDs and bioidentical hormones.

PLO Gel Highlighted Benefits

  • Ready-to-Use – Reduce compounding time
  • Enhanced transdermal penetration of lipophilic APIs
  • Contains Natural Emulsifier

Application

  • Pain Management
  • HRT

 

API Compatibility Chart

API

Common Concentration (s)

API

Common Concentration (s)

Amitriptyline

0.5 to 2%

Ketamine

2 to 5%

Baclofen

1 to 5 %

Ketoprofen

5 to 7.5%

Benzocaine

2 to 5 %

Lidocaine

2 to 5%

Buspirone

2.5 mg/ml

Menthol

1 to 5%

Camphor

1 to 2%

Methyl Salicylate                

5 to 7.5%

Capsaicin

 

0.75 to 1%

 

 

Nifedipine

0.5 to 5%

Cyclobenzaprine

0.5 to 2%

Piroxicam

5 to 7%

Dehydroepiandrosterone

1 to 2.5%

 

Pentoxiphyline

3 to 5%

Diclofenac

2.5-7.5%

Progesterone

1 to 5%

Diltiazem

 

2 to 5%

Promethazine

2.5 to 5%

Estradiol

0.1 to 1 mg/ml

Sildenafil

 

1%

Estriol

 

0.2 to 2 mg/ml

Tadalafil

0.2%

Fluoxetine

5 to 7.5%

Testosterone

0.5 to 2.5%

Gabapentin

 

3 to 6%

Tetracaine

3 to 5%

Ibuprofen

5 to 7 %

   

 

***The above recommended concentrations are for transdermal application. The concentration is required to be adjusted for any other route of administration such as mucosal, vaginal or rectal delivery.

 

Compounding Tips:

Ethoxy Diglycol, Glycerin, Mineral oil or Propylene Glycol are recommended as levigating agent.

 

Examples of compounding formulations with PLO Gel

Diclofenac 5% in PLO Gel

Diclofenac 5% Cyclobenzaprine 2% in PLO Gel

Progesterone 5% in PLO Gel

Diclofenac 3% Lidocaine 2% Ketamine 2% in PLO Gel

Gabapentin 5% Lidocaine 2% in PLO Gel

Ketoprofen 5% in PLO Gel

 

PLO Gel Physicochemical Characteristics

pH

5.5 – 6.5

Viscosity

150,000 – 250,000 CPS

Color

Ivory

Dosage Form

Gel

 

 

 

Disclaimer: Transderma Pharmaceuticals Inc. has provided the formula and instructions above as a model for educational purposes only on the basis of recognized compendia and texts or references. Transderma Pharmaceuticals Inc. takes no responsibility for the validity or accuracy of this information or for its safety or effectiveness, nor for any use thereof, which is at the sole risk of the licensed pharmacist. Adjustments may be needed to meet specific patient needs and in accordance with a licensed prescriber’s prescription. The pharmacist must employ appropriate tests to determine the stability of this suggested formula. Transderma Pharmaceuticals Inc., its owners, officers, agents, contractors, affiliates and employees cannot be held liable to any person or entity concerning claims, loss or damage caused by, or alleged to be caused by, directly or indirectly, the use or misuse of the information contained in this suggested formula. In all cases, it is the responsibility of the licensed pharmacist to know the law, to compound any finished product and to dispense these products in accordance with Health Canada and FDA guidelines and appropriate Provincial Drug Schedules and Provincial or Territorial Pharmacy Practice Standards.

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