Methods of Compounding Transderma and drug
A finished product of drug incorporated in Transderma is prepared by compounding the prescribed amounts of Transderma Organic/Lecithin Isopropyl Palmitate Solution (A) and Transderma Hydrophilic/Pluronic Gel (B) with alcohol and drug to obtain the desired quantity ready for dispensing.
- Disperse drug in alcohol in a mortar. Add to (A) and mix until uniformly dispersed or dissolved.
- Gradually incorporate (B) with the mixture of (A) and drug with vigorous trituration until gel is formed.
Recomendation
- Store Transderma Organic/Lecithin Isopropyl Palmitate Solution at room temperature, and Transderma Hydrophilic/Pluronic Gel in the refrigerator. NOTE: Transderma Hydrophilic/Pluronic Gel is solid at room temperature, and liquefies at refrigerated temperature.
- Warm Transderma Hydrophilic to about 10°C prior to compounding to improve the rate of the gelling process.
- Thorough dispersion or dissolution of drug in Transderma Organic/Lecithin Isopropyl Palmitate Solution is important before incorporating Transderma Hydrophilic in order to obtain best results.
- If greater than 2% drug is used, reduce the alcohol content, to about 5%, to obtain a more coherent gel.
The proportions of materials to be used to make various quantities of Transderma containing 2% drug are outlined below:
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