Methods of Compounding Transderma and drug
A finished product of drug incorporated in Transderma is prepared by compounding the prescribed amounts of Transderma Organic/Lecithin Isopropyl Palmitate Solution (A) and Transderma Hydrophilic/Pluronic Gel (B) with alcohol and drug to obtain the desired quantity ready for dispensing.
- Disperse drug in alcohol in a mortar. Add to (A) and mix until uniformly dispersed or dissolved.
- Gradually incorporate (B) with the mixture of (A) and drug with vigorous trituration until gel is formed.
The proportions of materials to be used to make various quantities of Transderma containing 2% drug are outlined below:
- Store Transderma Organic/Lecithin Isopropyl Palmitate Solution at room temperature, and Transderma Hydrophilic/Pluronic Gel in the refrigerator. NOTE: Transderma Hydrophilic/Pluronic Gel is solid at room temperature, and liquefies at refrigerated temperature.
- Warm Transderma Hydrophilic to about 10°C prior to compounding to improve the rate of the gelling process.
- Thorough dispersion or dissolution of drug in Transderma Organic/Lecithin Isopropyl Palmitate Solution is important before incorporating Transderma Hydrophilic in order to obtain best results.
- If greater than 2% drug is used, reduce the alcohol content, to about 5%, to obtain a more coherent gel.