Products

TD PLO GEL KIT

Introduction

Tranderma PLO Kits are conveniently packed with three key components required for making PLO gel (Premium Lecithin Organogel) in separate bottles. This kit enables the pharmacists to incorporate APIs during the formulation process which will result in a more stable finished product and enhanced transdermal delivery of APIs. PLO kit is an ideal option for compounding multiple APIs with high concentration for the pain management and HRT.

Available Sizes:

100G, 500G, 1KG

Where to buy

Product Description
Where to Buy

Tranderma PLO Kits contains three key components of PLO gel in separate bottles: Organic phase, Hydrophilic phase, and solvent. With the versatile PLO Kit, the finished product can be customized to meet the unique compounding needs of the prescription, yet is conveniently packed for ease of preparation by the pharmacist.

PLO Kit Highlighted Benefits

Convenient
Multiple APIs with high concentration can be incorporated
Enhanced transdermal delivery
Improved stability
Natural emulsifier
Paraben free

Application

Pain Management
HRT

API	Common Concentration (s)	API	Common Concentration (s)
Amitriptyline	0.5 to 2%	Ketamine HCl	2 to 5%
Baclofen	1 to 5 %	Ketoprofen	5 to 20%
Benzocaine	2 to 5 %	Lidocaine HCl	2 to 10%
Buspirone	2.5 mg/ml	Menthol	1 to 10%
Camphor	1 to 2%	Methyl Salicylate	5 to 15%
Capsaicin	0.75 to 1%	Nifedipine	0.5 to 10%
Cyclobenzaprine	0.5 to 2%	Piroxicam	5 to 10%
Dehydroepiandrosterone	1 to 2.5%	Pentoxiphyline	3 to 5%
Diclofenac	2.5-20%	Progesterone	1 to 5%
Diltiazem	2 to 5%	Promethazine	2.5 to 5%
Estradiol	0.1 to 1 mg/ml	Sildenafil	1%
Estriol	0.2 to 2 mg/ml	Tadalafil	0.2%
Fluoxetine	5 %	Testosterone	0.5 to 2.5%
Gabapentin	6%	Tetracaine	3 to 5%
Ibuprofen	10 to 20%

***The above recommended concentrations are for transdermal application. The concentration is required to be adjusted for any other route of administration such as mucosal, vaginal or rectal delivery.

Compounding Procedure

Using an appropriate size mortar and pestle levigate API with solvent (Ethoxy Diglycol).
Add Organic phase and mix until uniformly dispersed or dissolved.
Add Hydrophilic phase by geometrical method to the mix of A and B. Mix well until a homogenous gel is formed.

Compounding Tips

Store Organic phase at room temperature, and Hydrophilic phase in the refrigerator. NOTE: Hydrophilic is made of a thermoreversible polymer. It is solid at room temperature, and liquefies at refrigerated temperature.
Warm Hydrophilic phase to about 10°C prior to compounding to improve the rate of the gelling process.
Complete dispersion or dissolution of API in Organic phase is important before incorporating Hydrophilic in order to obtain best results.

Diclofenac 10% in PLO Gel (Kit)	Diclofenac 10% Cyclobenzaprine 2% in PLO Gel (Kit)	Progesterone 5% in PLO Gel (Kit)
Diclofenac 10% Lidocaine 4% Ketamine 4% in PLO Gel (Kit)	Gabapentin 5% Lidocaine 4% in PLO Gel (Kit)	Ketoprofen 20% in PLO Gel (Kit)

Disclaimer: Transderma Pharmaceuticals Inc. has provided the formula and instructions above as a model for educational purposes only on the basis of recognized compendia and texts or references. Transderma Pharmaceuticals Inc. takes no responsibility for the validity or accuracy of this information or for its safety or effectiveness, nor for any use thereof, which is at the sole risk of the licensed pharmacist. Adjustments may be needed to meet specific patient needs and in accordance with a licensed prescriber’s prescription. The pharmacist must employ appropriate tests to determine the stability of this suggested formula. Transderma Pharmaceuticals Inc., its owners, officers, agents, contractors, affiliates and employees cannot be held liable to any person or entity concerning claims, loss or damage caused by, or alleged to be caused by, directly or indirectly, the use or misuse of the information contained in this suggested formula. In all cases, it is the responsibility of the licensed pharmacist to know the law, to compound any finished product and to dispense these products in accordance with Health Canada and FDA guidelines and appropriate Provincial Drug Schedules and Provincial or Territorial Pharmacy Practice Standards.

Toll Free: 1.800.663.1002
Website: www.xenexlabs.com

Xenex has been supplying the highest quality products, delivered by qualified professionals to the Canadian compounding profession for over 30 years. Xenex focuses on the compounding pharmacist and has built a valuable set of support services to provide the pharmacist with education, formulation support and competitively priced product, delivered by a knowledgeable sales and customer services team.